Abstract Microwave synthesis technique opens new avenues for the synthesis of many compounds. A novel and simple method has been developed for the synthesis of 1-(2, 4- dinitrophenyl) pyrazolidine-3, 5-dione and 1-(2, 4-dinitrophenyl)-3, 5-dimethyl-1H-pyrazole derivatives under microwave irradiation. These compounds exhibit mild to moderate antimircrobial activity against different strains of bacteria (eg E. coli, P. aeruginosa, S. ...