Synthesis and biological properties of new hexapeptide substrates for vitamin K dependent carboxylase. Evidence for X-Pro cis/trans amide bond interconversions in …

…, M Kawai, HL Goodman, JW Suttie

Index: Rich, Daniel H.; Kawai, Megumi; Goodman, Hedda L.; Suttie, John W. Journal of Medicinal Chemistry, 1983 , vol. 26, # 6 p. 910 - 916

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Abstract

Glu-Glu-Pro-Cys-] have been synthesized and evaluated as substrates for vitamin K dependent carboxylase. These new hexapeptides are moderately good substrates for the carboxylase but do not significantly inhibit carboxylation of Phe-Leu-Glu-Glu-Leu, a good substrate for the enzyme. Based on proton and carbon-13 NMR experiments, it is established that the conformation of sequence 18-23, which contains proline at position ...