The pharmacological importance of many sulfanilamide derivatives containing a nitrogen heterocycle suggested that the isoquinoline nucleus,. present in a variety of alkaloids of pronounced physiological activity and low toxicity, might profitably be incorporated in such a compound. To this end a series of 1-alkyl-2-sulfanilyl-1, 2, 3, 4-tetrahydroisoquinolines and 5-sulfanilamidoisoquinoline have been synthesized. The alkyl groups in the former have ...
