Journal of Heterocyclic Chemistry

Irreversible enzyme inhibitors. XCI. candidate active??site directed irreversible inhibitors of thymidylate synthetase. II. 2??amino??6??methyl??5??(p??tolylsulfonamidopropyl)?? …

BR Baker, JK Coward

Index: Baker,B.R.; Coward,J.K. Journal of Heterocyclic Chemistry, 1967 , vol. 4, p. 202 - 208

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Citation Number: 2

Abstract

Abstract Three derivatives of 2-amino-6-methyl-5-(p-tolylsulfonamidopropyl)-4-pyrimidinol (I) with N-substituents on the sulfonamide group, namely bromoacetamidopropyl (XVI), m- bromoacetamidobenzyl (XXIVa), and p-bromoacetamidobenzyl (XXIVb), were synthesized as candidate active-site-directed irreversible inhibitors of thymidylate synthetase. The bromoacetamidopropyl derivative,(XVI), the p-bromoacetamidobenzyl derivative (XXIVb), ...