9??deazapurine nucleosides. The synthesis of certain N??5??2′??deoxy?螃漫?D??erythropentofuranosyl and N??5?螃漫?D??arabinofuranosylpyrrolo [3, 2??d] pyrimidines

…, HB Cottam, SB Larson, RK Robins

Index: Girgis, Nabih S.; Cottam, Howard B.; Larson, Steven B.; Robins, Roland K. Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 821 - 827

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Citation Number: 11

Abstract

Abstract A number of 2, 4-disubstituted pyrrolo [3, 2-d] pyrimidine N-5 nucleosides were prepared by the direct glycosylation of the sodium salt of 2, 4-dichloro-5H-pyrrolo [3, 2-d] pyrimidine (3) using 1-chloro-2-deoxy-3, 5-di-O-(p-toluoyl)-α-D-erythropentofuranose (1) and 1-chloro-2, 3, 5-tri-O-benzyl-α-D-arabinofuranose (11). The resulting N-5 glycosides, 2, 4-dichloro-5-(2-deoxy-3, 5-di-O-(p-toluoyl)-β-D-erythropentofuranosyl)-5H-pyrrolo-[3, 2-d] ...