Microwave-assisted solvent-free synthesis of enantiomerically pure N-(tert-Butylsulfinyl) imines

JF Collados, E Toledano, D Guijarro…

Index: Collados, Juan F.; Toledano, Estefania; Guijarro, David; Yus, Miguel Journal of Organic Chemistry, 2012 , vol. 77, # 13 p. 5744 - 5750

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Citation Number: 44

Abstract

A simple, environmentally friendly, and very efficient procedure for the synthesis of optically pure N-(tert-butylsulfinyl) imines has been developed with microwave-promoted condensation of aldehydes and ketones using (R)-2-methylpropane-2-sulfinamide in the presence of Ti (OEt) 4, under solvent-free conditions. This procedure allows for the preparation of a variety of sulfinyl aldimines with excellent yields and purities in only 10 ...