Arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 2: Optimization of P1 and N-aryl

PB Alper, H Liu, AK Chatterjee, KLT Nguyen…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 6 p. 1486 - 1490

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Citation Number: 15

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... Scheme 3 shows the chemistry used to access the compounds that required transformation of the side chain after coupling in Scheme 2. In this scheme, R 6 refers to an alkyl, aryl or carbonyl group. ...