Tetrahedron

A general and efficient method for the synthesis of benzo-(iso) quinoline derivatives

V Mamane, F Louërat, J Iehl, M Abboud, Y Fort

Index: Mamane, Victor; Louerat, Frederic; Iehl, Julien; Abboud, Mohamed; Fort, Yves Tetrahedron, 2008 , vol. 64, # 47 p. 10699 - 10705

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Citation Number: 24

Abstract

A new, short and efficient synthesis of substituted benzo-(iso) quinoline derivatives is reported. The methodology is based on a Suzuki or Negishi cross-coupling followed by a cyclization reaction induced by t-BuOK in DMF to form the central ring. This approach allowed the synthesis of all four benzo-(iso) quinoline isomers and the substitution of each ring of the benzo-(iso) quinoline core.