Synthesis of N-(2-aminoethyl)-and N-(3-aminopropyl) cytisine

…, NZ Baibulatova, NM Vlasova, LV Spirikhin…

Index: Shishkin; Lobov; Baibulatova; Vlasova; Spirikhin; Dokichev Chemistry of Natural Compounds, 2012 , vol. 48, # 3 p. 436 - 439 Khim. Prir. Soedin., 2012 , vol. 48, # 3 p. 393 - 396,4

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Citation Number: 4

Abstract

2-(N-cytisinyl) acetamide or 3-(N-cytisinyl) propanamide were prepared by treatment of the methyl esters of N-cytisinylacetic or 3-(N-cytisinyl) propanoic acids with aqueous NH 4 OH. N-(2-Aminoethyl)-or N-(3-aminopropyl) cytisine was synthesized by reduction of the amide with (i-Bu) 2 AlH.