Regioselective synthesis, characterization and antimicrobial evaluation of S-glycosides and S, N-diglycosides of 1, 2-Dihydro-5-(1H-indol-2-yl)-1, 2, 4-triazole-3-thione

H El Sayed, H El Sayed, MEDA El Fattah…

Index: El Ashry, El Sayed H.; El Tamany, El Sayed H.; Abd El Fattah, Mohy El Din; Boraei, Ahmed T. A.; Abd El-Nabi, Heba M. European Journal of Medicinal Chemistry, 2013 , vol. 66, p. 106 - 113

Full Text: HTML

Citation Number: 9

Abstract

Abstract Glycosylation of 1, 2-Dihydro-5-(1H-indol-2-yl)-1, 2, 4-triazole-3-thione with 2, 3, 4, 6-tetra-O-acetyl-α-d-glucopyranosyl bromide, 2, 3, 4, 6-tetra-O-acetyl-α-d-galactopyranosyl bromide and 2-acetamido-3, 4, 6-tri-O-acetyl-2-deoxy-α-d-glucopyranosyl chloride was investigated in the presence of Et 3 N and K 2 CO 3 as acid scavengers. A regioselective S- glycosides were obtained by using Et 3 N whereas, using K 2 CO 3 gave a mixtures of two ...