Derivatives of Imidazo [2, 1-b] benzoxazole (Studies on Heterocyclic Compounds. VIII)

H OGURA, T ITOH, S SUGIMOTO

Index: Ogura,H. et al. Chemical and Pharmaceutical Bulletin, 1970 , vol. 18, p. 2204 - 2207

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Citation Number: 6

Abstract

Imidazo [2, 1-b] benzoxazoles which have a new ring system were synthesized. Condensation reaction of 2-aminobenzoxazole (I) and bromoacetone afforded 2-imino-3-(2- oxopropyl)-2, 3-dihydrobenzoxazole (IIa). When phenacyl bromide was used instead of bromoacetone, 2-imino-3-phenacyl-2, 3-dihydrobenzoxazole (IVa) was obtained. Cyclization of these imino-derivatives afforded imidazo [2, 1-b] benzoxazoles. On the other ...