Tetrahedron letters

Facile access to 2′-O-acyl prodrugs of 1-(β-d-arabinofuranosyl)-5 (E)-(2-bromovinyl) uracil (BVAraU) via regioselective esterase-catalyzed hydrolysis of 2′ 3′, 5′- …

PG Baraldi, R Bazzanini, S Manfredini, D Simoni…

Index: Baraldi, Pier G.; Bazzanini, Rita; Manfredini, Stefano; Simoni, Daniele; Robins, Morris J. Tetrahedron Letters, 1993 , vol. 34, # 19 p. 3177 - 3180

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Citation Number: 17

Abstract

Abstract Treatment of 1-(2, 3, 5-tri-O-acetyl-β-d-arabinofuranosyl)-5-[2-(trimethylsilyl)-vinyl] uracil (3) with pyridinium bromide perbromide and deacetylation gave BVAraU (2). Pig liver esterase (EC 3.1. 1.1) catalysed the regioselective hydrolysis of 1-(2, 3, 5-tri-O-acyl-β-d- arabinofuranosyl) uracil derivatives to their 2′-O-acyl monoesters.