Tetrahedron letters

Solid-phase synthesis of 2-imidazolidinethiones via Mitsunobu reaction of N-(2-hydroxyethyl) thioureas

HS Jeon, JH Yoo, JN Kim, TH Kim

Index: Jeon, Hyun Suk; Yoo, Je Hwa; Kim, Jae Nyoung; Kim, Taek Hyeon Tetrahedron Letters, 2007 , vol. 48, # 3 p. 439 - 441

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Citation Number: 5

Abstract

This letter reports the solid-phase synthesis of 2-imidazolidinethiones via the N-cyclization of N-(2-hydroxyethyl) thioureas using the Mitsunobu reaction in good yield and purity. This process employed the reductive amination of an ArgoGel-MB-CHO resin to anchor the aminoalcohols, followed by a reaction with isothiocyanates to give the resin-attached N-(2- hydroxyethyl) thioureas. Cleavage of the 2-imidazolidinethiones was performed with ...