Homochiral carbon branched piperidines from carbon branched sugar lactones: 4-C-methyl-deoxyfuconojirimycin (DFJ) and its enantiomer—removal of glycosidase …

DJ Hotchkiss, A Kato, B Odell, TDW Claridge…

Index: Hotchkiss, David J.; Kato, Atsushi; Odell, Barbara; Claridge, Timothy D.W.; Fleet, George W.J. Tetrahedron Asymmetry, 2007 , vol. 18, # 4 p. 500 - 512

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Citation Number: 19

Abstract

The value of readily available 2-C-methyl aldonic acids in short syntheses of carbon branched piperidines containing quaternary centers is demonstrated. The effect of the introduction of a 4-C-methyl group into piperidine imino sugar inhibitors of l-fucosidases and d-galactosidases is reported.