A series of 2-aryl-2H-pyrazolo [4, 3-c] quinolin-3-ones derivatives 6 and 7 was conveniently prepared. A multistep synthesis was carried out starting from dichloro-and bromoanilines (1a– b) and diethyl 2-(ethoxymethylene) malonate using a slightly modified Gould-Jacobs reaction. In this work we present a novel chlorination strategy to prepare quinoline derivatives 4 in excellent yields as key intermediates in the synthesis of the target ...
