Thieno [3, 2-d] pyrimidin-4 (3H)-one derivatives as PDK1 inhibitors discovered by fragment-based screening

ACH Lee, PM Ramanujulu, A Poulsen…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 12 p. 4023 - 4027

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Citation Number: 3

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... Compound, Chemical structure, MW, LE a, PDK1 IC 50 (μM) 13. ... potency and high ligand efficiency prompted us to select the thieno[3,2-d]pyrimidin- 4(3H)-ones 4 and 5 as our first-choice start points for medicinal chemistry and we now ...