Derivatives of 17-(2-methylallyl)-substituted noroxymorphone: variation of the delta address and its effects on affinity and selectivity for the delta opioid receptor

…, CM Dersch, RB Rothman, AE Jacobson…

Index: Ullrich; Dersch; Rothman; Jacobson; Rice Bioorganic and medicinal chemistry letters, 2001 , vol. 11, # 21 p. 2883 - 2885

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Citation Number: 11

Abstract

In an effort to establish the importance of the N-(2-methylallyl) substituent in the noroxymorphone series, several derivatives have been synthesized, retaining that N- substituent and modifying the δ address moiety. A few compounds showed moderate binding affinity and selectivity for the δ receptor; none displayed a pharmacological profile as exceptional as N-(2-methylallyl) noroxymorphindole. A second study showed that 3-O- ...