Identification, synthesis, and activity of novel blockers of the voltage-gated potassium channel Kv1. 5

S Peukert, J Brendel, B Pirard…

Index: Journal of Medicinal Chemistry, , vol. 46, # 4 p. 486 - 498

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Citation Number: 89

Abstract

... Journal of Medicinal ... Aventis Pharma Deutschland GmbH, Medicinal Chemistry and DG Cardiovascular, D-65926 Frankfurt/Main, Germany. J. Med. ... the risk of potentially lethal ventricular proarrhythmia (CAST-trial, 3 SWORD-trial 4 ). Therefore, there is an unmet medical need for ...