Synthesis and biological evaluation of berberine analogues as novel up-regulators for both low-density-lipoprotein receptor and insulin receptor

YX Wang, YP Wang, H Zhang, WJ Kong, YH Li…

Index: Wang, Yan-Xiang; Wang, Yu-Ping; Zhang, Hao; Kong, Wei-Jia; Li, Ying-Hong; Liu, Fei; Gao, Rong-Mei; Liu, Ting; Jiang, Jian-Dong; Song, Dan-Qing Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 21 p. 6004 - 6008

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Citation Number: 47

Abstract

Berberine (BBR) is a natural compound with up-regulating activity on both low-density- lipoprotein receptor (LDLR) and insulin receptor (InsR). This one-drug-multiple-target characteristic might be suitable for the treatment of metabolic syndrome. In searching for up- regulators effective for both LDLR and InsR expression, the structure–activity relationship (SAR) analysis for BBR analogues was done. Fourteen BBR analogues were designed, ...

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