1-(2-Deoxy-2-fluoro-. beta.-D-arabinofuranosyl)-5-ethyluracil. A highly selective antiherpes simplex agent

…, HG Howell, PR Brodfuehrer, DA Benigni…

Index: Mansuri; Ghazzouli; Chen; Howell; Brodfuehrer; Benigni; Martin Journal of Medicinal Chemistry, 1987 , vol. 30, # 5 p. 867 - 871

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Citation Number: 35

Abstract

6 R: IX= H the presence of the virus-specified thymidine kina~ e.~ These nucleosides are monophosphorylated on the 5'-hydroxyl group4 by this kinase and subsequently converted to the 5'-db5 and then the 5/-triphosphates by cellular kinases. The triphosphate derivative inhibits virus DNA polymerase and thereby inhibits virus replication. 6 Inasmuch as these compounds are poor substrates for cellular kinases, the initial phosphorylation by the virus ...