N'-[(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl) methylene] 2/4-substituted hydrazides: Synthesis and anticonvulsant activity

D Kaushik, SA Khan, G Chawla, S Kumar

Index: Kaushik, Darpan; Khan, Suroor Ahmad; Chawla, Gita; Kumar, Suresh European Journal of Medicinal Chemistry, 2010 , vol. 45, # 9 p. 3943 - 3949

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Citation Number: 83

Abstract

A series of N'-[(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl) methylene] 2/4-substituted hydrazides were synthesized using appropriate synthetic route and characterized by elemental analysis and spectral data. The anticonvulsant activity of some of the synthesized compounds were evaluated against maximal electroshock induced seizure (MES) and subcutaneous pentylenetetrazol (scPTZ) induced seizure models in mice. The ...