An Improved Procedure for the Preparation of 2, 2-Bis [2-[4 (S)-tert-butyl-1, 3-oxazolinyl]] propane [(S, S)-tert-Butylbis (oxazoline)] and Derived Copper (II) Complexes

…, GS Peterson, JS Johnson, DM Barnes…

Index: Evans, David A.; Peterson, Gretchen S.; Johnson, Jeffrey S.; Barnes, David M.; Campos, Kevin R.; Woerpel, Keith A. Journal of Organic Chemistry, 1998 , vol. 63, # 13 p. 4541 - 4544

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Citation Number: 166

Abstract

The general utility of C2-symmetric bis (oxazoline)(box) ligands in copper-catalyzed asymmetric transformations has been demonstrated in a number of processes, including cyclopropanation, 1 olefin aziridination, 2 Diels-Alder, 3 Mukaiyama aldol, 4 and allylic oxidation reactions. 5 Several methods for the synthesis of these ligands have been reported with moderate to good yields. 6 The previously reported synthesis of (S, S)-tert- ...