Helvetica chimica acta

Monocyclic, substituted imidazoles as glycosidase inhibitors

P Magdolen, A Vasella

Index: Magdolen, Peter; Vasella, Andrea Helvetica Chimica Acta, 2005 , vol. 88, # 9 p. 2454 - 2469

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Citation Number: 11

Abstract

Abstract A range of 4-monosubstituted and 2, 4-disubstituted 1H-imidazoles and 1H- imidazole-1-ethanols (R [BOND] C (4): CH 2 CH 2 Ph, CHOHCH 2 Ph, Ph, or Me; R [BOND] C (2): CH 2 OH, CHOHCH 2 OH, CN, or CH 2 NHAc) were prepared and tested as inhibitors of α-and β-glucosidases and of a β-galactosidase. A new access to 4-(2-phenylethyl)-1H- imidazoles starting from 4-phenylbutan-1-ol was elaborated. The strongest inhibitors are ...