Abstract A range of 4-monosubstituted and 2, 4-disubstituted 1H-imidazoles and 1H- imidazole-1-ethanols (R [BOND] C (4): CH 2 CH 2 Ph, CHOHCH 2 Ph, Ph, or Me; R [BOND] C (2): CH 2 OH, CHOHCH 2 OH, CN, or CH 2 NHAc) were prepared and tested as inhibitors of α-and β-glucosidases and of a β-galactosidase. A new access to 4-(2-phenylethyl)-1H- imidazoles starting from 4-phenylbutan-1-ol was elaborated. The strongest inhibitors are ...