Design, synthesis, and BK channel-opening activity of hexahydrodibenzazepinone derivatives

…, K Furukawa, H Tsuru, S Adachi-Akahane…

Index: Tashima, Toshihiko; Toriumi, Yoshimi; Mochizuki, Yumi; Nonomura, Taro; Nagaoka, Satoru; Furukawa, Katsuo; Tsuru, Hiromichi; Adachi-Akahane, Satomi; Ohwada, Tomohiko Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 23 p. 8014 - 8031

Full Text: HTML

Citation Number: 26

Abstract

In order to explore new scaffolds for large-conductance Ca2+-activated K+ channel (BK channel) openers, we carried out molecular design and synthesis on the basis of the following two concepts:(1) introduction of a heteroatom into the dehydroabietic acid (BK channel opener) skeleton would allow easier introduction of substituents.(2) Because of the fourfold symmetrical structure of BK channels, dimeric compounds in which two ...