Identification of novel PPARα ligands by the structural modification of a PPARγ ligand

…, H Fujieda, T Suzuki, N Yoshida, H Nakagawa…

Index: Usui, Shinya; Fujieda, Hiroki; Suzuki, Takayoshi; Yoshida, Naoaki; Nakagawa, Hidehiko; Miyata, Naoki Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 12 p. 3249 - 3254

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Citation Number: 4

Abstract

To develop novel PPARα ligands, we designed and synthesized several 3-{3-[2- (nonylpyridin-2-ylamino) ethoxy] phenyl} propanoic acid derivatives. Compound 10, the meta isomer of a PPARγ agonist 1, has been identified as a PPARα ligand. The introduction of methyl and ethyl groups at the C-2 position of the propanoic acid of 10 further improved the PPARα-binding potency.