Biotransformations of morphine alkaloids by fungi: N-demethylations, oxidations, and reductions

…, H Leisch, A Moudra, B Allen, V De Luca…

Index: Chaudhary, Vigi; Leisch, Hannes; Moudra, Alena; Allen, Blake; De Luca, Vincenzo; Cox, D. Phillip; Hudlicky, Tomas Collection of Czechoslovak Chemical Communications, 2009 , vol. 74, # 7-8 p. 1179 - 1193

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Citation Number: 21

Abstract

Abstract Morphine alkaloids and some of its derivatives (morphine, codeine, thebaine, oripavine, hydrocodone, and oxycodone) were subjected to fermentations with six fungal strains. The alkaloids were transformed to a variety of products via biological oxidations, reductions, and oxidative demethylations. The strain Cunninghamella echinulata proved to be the most effective for demethylations of all of the above compounds, except for ...