3-Nitrobenzanthrone, a powerful bacterial mutagen and suspected human carcinogen found in diesel exhaust and airborne particulates

…, T Watanabe, T Hirayama, Y Hisamatsu

Index: Enya, Takeji; Suzuki, Hitomi; Watanabe, Tetsushi; Hirayama, Teruhisa; Hisamatsu, Yoshiharu Environmental Science and Technology, 1997 , vol. 31, # 10 p. 2772 - 2776

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Citation Number: 299

Abstract

3-Nitrobenzanthrone (3-nitro-7 H-benz [d, e] anthracen-7-one) was isolated from the organic extracts of both diesel exhaust and airborne particles and was identified as a new class of powerful direct mutagen. Its mutagenicity by Ames Salmonella assay is very high (208 000 revertants/nmol in Salmonella typhimurium TA98 and 6 290 000 revertants/nmol in YG1024) and compares with that of 1, 8-dinitropyrene, which is the direct mutagen of strongest ...