Discovery, SAR, synthesis, pharmacokinetic and biochemical characterization of A-192411: a novel fungicidal lipopeptide-(I)

…, B Steiner, DA Dickman, H Ding, A Clairborne…

Index: Wang, Weibo; Li, Qun; Hasvold, Lisa; Steiner, Beth; Dickman, Daniel A.; Ding, Hong; Clairborne, Akyio; Chen, Hui-Ju; Frost, David; Goldman, Robert C.; Marsh, Kennan; Hui, Yu-Hua; Cox, Brian; Nilius, Angela; Balli, Darlene; Lartey, Paul; Plattner, Jacob J.; Bennani, Youssef L. Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 3 p. 489 - 493

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Citation Number: 14

Abstract

The echinocandin class of cyclic lipopepetides has been simplified to discover potent antifungal compounds. Namely A-192411 shows good in vitro activity against common pathogenic yeasts and has an acceptable safety window in vivo. Discovery, limited SAR, synthesis, biochemical and pharmaco-dynamic profiles of A-192411 are presented.