Design, synthesis and functional analysis of dansylated polytheonamide mimic: an artificial peptide ion channel

H Itoh, S Matsuoka, M Kreir, M Inoue

Index: Itoh, Hiroaki; Matsuoka, Shigeru; Kreir, Mohamed; Inoue, Masayuki Journal of the American Chemical Society, 2012 , vol. 134, # 34 p. 14011 - 14018

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Citation Number: 15

Abstract

We report herein the design, total synthesis, and functional analysis of a novel artificial ion channel molecule, designated as dansylated polytheonamide mimic (3). The channel 3 was designed based on an exceptionally potent cytotoxin, polytheonamide B (1). Our strategy for the development of synthetic ion channels, which could be easily derivatized for various functions, involved two key features. First, the structure of 1 was simplified by replacing ...