Copper-catalyzed oxidative trimerization of indoles by using TEMPO to construct quaternary carbon centers: the synthesis of 2-(1 H-indol-3-yl)-2, 3′-biindolin-3-ones

YB Kong, JY Zhu, ZW Chen…

Index: Kong, Yu-Bo; Zhu, Jia-Yi; Chen, Zheng-Wang; Liu, Liang-Xian Canadian Journal of Chemistry, 2014 , vol. 92, # 4 p. 269 - 273

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Citation Number: 4

Abstract

A simple, convenient, and efficient synthesis of 2-(1 H-indol-3-yl)-2, 3′-biindolin-3-one derivatives has been developed by the oxidative trimeric reaction of indoles using the TEMPO/CuCl2 catalyst system under ambient air. This methodology provides an alternative approach for the direct generation of all-carbon quaternary centers at the C-2 position of indoles.