N-Hydroxybenzimidazole inhibitors of ExsA MAR transcription factor in Pseudomonas aeruginosa: In vitro anti-virulence activity and metabolic stability

…, LK Garrity-Ryan, VJ Bartlett, KA Klausner…

Index: Grier, Mark C.; Garrity-Ryan, Lynne K.; Bartlett, Victoria J.; Klausner, Kevin A.; Donovan, Peter J.; Dudley, Caroline; Alekshun, Michael N.; Ken Tanaka; Draper, Michael P.; Levy, Stuart B.; Kim, Oak K. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 11 p. 3380 - 3383

Full Text: HTML

Citation Number: 22

Abstract

ExsA is a multiple adaptational response (MAR) transcription factor, regulating the expression of a virulence determinant, the type III secretion system (T3SS) in Pseudomonas aeruginosa. Non-cytotoxic, non-antibacterial N-hydroxybenzimidazoles were identified as effective inhibitors of ExsA-DNA binding, and their potential utility as anti-virulence agents for P. aeruginosa was demonstrated in a whole cell assay. Select N- ...