Synthesis of deuterium??labeled analogs of the lipid hydroperoxide??derived bifunctional electrophile 4??oxo??2 (E)??nonenal

JS Arora, T Oe, IA Blair

Index: Arora, Jasbir S.; Oe, Tomoyuki; Blair, Ian A. Journal of Labelled Compounds and Radiopharmaceuticals, 2011 , vol. 54, # 5 p. 247 - 251

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Abstract

Abstract Lipid hydroperoxides undergo homolytic decomposition into the bifunctional 4- hydroxy-2 (E)-nonenal and 4-oxo-2 (E)-nonenal (ONE). These bifunctional electrophiles are highly reactive and can readily modify intracellular molecules including glutathione (GSH), deoxyribonucleic acid (DNA) and proteins. Lipid hydroperoxide-derived bifunctional electrophiles are thought to contribute to the pathogenesis of a number of diseases. ONE ...