New antiproliferative compounds, dimethyl-5 H-pyrido [3, 2-a] phenoxazin-5-ones (1-6), tetrahydro-5 H-benzopyrido [2, 3-j] phenoxazin-5-ones (7-9), and 5 H-benzopyrido [3, 2-a] phenoxazin-5-ones (10-12) were synthesized and evaluated against representative human neoplastic cell lines. Dimethyl derivatives 1-6 were more active against carcinoma than leukemia cell lines. The tetrahydrobenzo derivatives 7-9 were scarcely active, whereas ...
