Tetrahedron

Reactivity of several deactivated 3-aminobenzo [b] thiophenes in the Buchwald–Hartwig C–N coupling. Scope and limitations

MJRP Queiroz, RC Calhelha, G Kirsch

Index: Queiroz, Maria-Joao R.P.; Calhelha, Ricardo C.; Kirsch, Gilbert Tetrahedron, 2007 , vol. 63, # 52 p. 13000 - 13005

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Citation Number: 17

Abstract

Di (hetero) arylamines were prepared in moderate to high yields by Buchwald–Hartwig C–N coupling of bromobenzenes bearing electron-withdrawing groups and of a bromobiphenyl with several methyl 3-aminobenzo [b] thiophene-2-carboxylates, using the coupling conditions for heteroaromatic amines [Pd (OAc) 2, Xantphos, Cs2CO3 in dioxane, 120° C]. The use of these aminobenzo [b] thiophenes as coupling components avoids the step of ...