Synthesis and biological evaluation of novel hydroquinone dimethyl ethers as potential anticancer and antimicrobial agents

I Chaaban, M El Sayeda, MA Mahran…

Index: Chaaban, Ibrahim; El Khawass, El Sayeda M.; Mahran, Mona A.; Abd El Razik, Heba A.; El Salamouni, Nehad S.; Abdel Wahab, Abeer E. Medicinal Chemistry Research, 2013 , vol. 22, # 8 p. 3760 - 3778

Full Text: HTML

Citation Number: 3

Abstract

Abstract The synthesis of two novel series of quinol dimethyl ethers linked to either various functionalities or to some biologically active nitrogenous heterocycles is described. Nine of the newly synthesized quinol dimethyl ethers 5a, b, 9b, 10a, d, 12a, b, and 13a, b were selected by the NCI and were tested initially at a single high dose (10 μM) in the full NCI 60 cell panel. Four of the screened quinol dimethyl ethers bearing unsubstituted ...