Synthesis, biological evaluation and QSAR study of a series of substituted quinazolines as antimicrobial agents

…, BM Mahajan, PS Brahmkshatriya, NK Shah

Index: Buha, Vipul M.; Rana, Dharmaraj N.; Chhabria, Mahesh T.; Chikhalia, Kishor H.; Mahajan, Bhushan M.; Brahmkshatriya, Pathik S.; Shah, Nisha K. Medicinal Chemistry Research, 2013 , vol. 22, # 9 p. 4096 - 4109

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Citation Number: 6

Abstract

Abstract A novel series of 1-N-substituted-3-(4-(5-(pyridin-3-yl)-1, 3, 4-oxadiazol-2-ylthio) quinazolin-6-yl) urea/thiourea derivatives (6a–6r) and 1-N-substituted-3-(7-(4- methylpiperazin-1-yl)-4-(5-(pyridin-3-yl)-1, 3, 4-oxadiazol-2-ylthio) quinazolin-6-yl) urea/thiourea derivatives (14a–14s) were synthesized and screened for antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, and ...