Rapid and Efficient Synthesis of High-Purity Fluorine-18 Labeled Haloperidol and Spiperone via the Nitro Precursor in Combination with a New HPLC Separation …

K Hashizume, N Hashimoto, Y Miyake

Index: Hashizume, Kazunari; Hashimoto, Naoto; Miyake, Yoshihiro Bulletin of the Chemical Society of Japan, 1997 , vol. 70, # 3 p. 681 - 687

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Citation Number: 5

Abstract

We have completed a convenient synthesis of fluorine-18 labeled butyrophenone neuroleptics from their nitro precursors. Thus, we have developed an efficient single-column HPLC system using a C 18-bonded vinyl alcohol copolymer gel (octadecyl polymer, ODP) column and strongly alkaline solvent systems for purifying of the 18 F-labeled butyrophenone neuroleptics obtained by a single-step 18 F-for-nitro exchange reaction. ...

~45%

~90%

Microwave-accelerated fluorodenitrations and nitrodehalogena...

[LaBeaume, Paul; Placzek, Michael; Daniels, Mathew; Kendrick, Ian; Ng, Patrick; McNeel, Melissa; Afroze, Roushan; Alexander, Abigail; Thomas, Rhiannon; Kallmerten, Amy E.; Jones, Graham B. Tetrahedron Letters, 2010 , vol. 51, # 14 p. 1906 - 1909]

Structure and orientation of the imidazolium cation at the r...

[Anjaiah, Siddam; Chandrasekhar, Srivari; Gree, Rene Advanced Synthesis and Catalysis, 2004 , vol. 346, # 11 p. 1329 - 1334]

Synthesis of high specific activity [75Br]-and [77Br] Brompe...

[Moerlein, Stephen M.; Stoecklin, Gerhard L. Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1319 - 1324]

Structure and orientation of the imidazolium cation at the r...

[Anjaiah, Siddam; Chandrasekhar, Srivari; Gree, Rene Advanced Synthesis and Catalysis, 2004 , vol. 346, # 11 p. 1329 - 1334]