Enantioselective α-arylation of carbonyls via Cu (I)-bisoxazoline catalysis

JS Harvey, SP Simonovich, CR Jamison…

Index: Harvey, James S.; Simonovich, Scott P.; Jamison, Christopher R.; MacMillan, David W. C. Journal of the American Chemical Society, 2011 , vol. 133, # 35 p. 13782 - 13785

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Citation Number: 100

Abstract

The enantioselective α-arylation of both lactones and acyl oxazolidones has been accomplished using a combination of diaryliodonium salts and copper catalysis. These mild catalytic conditions provide a new strategy for the enantioselective construction and retention of enolizable α-carbonyl benzylic stereocenters, a valuable synthon for the production of medicinal agents.