An Asymmetric, Chemo??Enzymatic Synthesis of O??Acetylcyanohydrins

YN Belokon, AJ Blacker, LA Clutterbuck…

Index: Belokon, Yuri N.; Blacker, A. John; Clutterbuck, Lisa A.; Hogg, David; North, Michael; Reeve, Christopher European Journal of Organic Chemistry, 2006 , # 20 p. 4609 - 4617

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Citation Number: 12

Abstract

Abstract A one-pot chemo-enzymatic synthesis of highly enantiomerically enriched O- acetylcyanohydrins has been developed. The bimetallic (salen) titanium complex 1 is used to convert aldehydes into nonracemic (R)-O-acetylcyanohydrins with 61 to 93% enantiomeric excess. A lipase enzyme is then used to hydrolyse the unwanted (S) enantiomer of the product, leaving (R)-O-acetylcyanohydrins with 80 to> 99% ...