1-[2-(2-hydroxyalkyl) phenyl] ethanone: a new photoremovable protecting group for carboxylic acids

WN Atemnkeng, LD Louisiana, PK Yong, B Vottero…

Index: Atemnkeng, Walters N.; Louisiana II, Larry D.; Yong, Promise K.; Vottero, Breanne; Banerjee, Anamitro Organic Letters, 2003 , vol. 5, # 23 p. 4469 - 4471

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Citation Number: 22

Abstract

A new photoremovable protecting group for carboxylic acids is introduced. The protecting group 1-[2-(2-hydroxyalkyl) phenyl] ethanone, HAPE, is used to protect various carboxylic acids. When photolyzed, the protected compound releases the acid in 70-85% isolated yields. The synthesis and the results of photorelease of the protected acids are presented here.