Journal of the Chemical Society C: Organic

Rearrangement reactions of dimethyl 2, 7-dimethyl-3 H-azepine-3, 6-dicarboxylate

M Anderson, AW Johnson

Index: Anderson,M.; Johnson,A.W. Journal of the Chemical Society [Section] C: Organic, 1966 , p. 1075 - 1078

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Citation Number: 1

Abstract

The base-catalysed reaction of dimethyl 4-chloromethyl-1, 4-dihydro-2, 6-dimethylpyridine- 3, 5-dicarboxylate to derivatives of both 4H-and 3H-azepines can be reversed by hydrochloric acid. Dimethyl 2, 7-dimethyl-3H-azepine-3, 6-dicarboxylate rearranges to methyl (5-methoxycarbonyl-2, 6-dimethyl-3-pyridyl) acetate under the action of either sodium methoxide or mineral acids. With ethanolic hydrochloric acid, two other products have ...