A difluorosulfide as a Freon-free source of phosphonodifluoromethyl carbanion

A Henry-dit-Quesnel, L Toupet, JC Pommelet…

Index: Henry-dit-Quesnel, Arnaud; Toupet, Loic; Pommelet, Jean-Claude; Lequeux, Thierry Organic and Biomolecular Chemistry, 2003 ,  vol. 1,  # 14  p. 2486 - 2491

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Citation Number: 27

Abstract

The synthesis of difluoromethylphosphonates is becoming difficult due to environmental protective laws restricting the use of HCFCs and CFCs as starting chemicals. To circumvent this limitation, we report the preparation of a thioether as a new source of the lithiodifluoromethylphosphonate. This methodology avoiding the use of HCFCs involves a selective fluorination of sulfide followed by a thiaphilic addition of an organometallic ...