Smmary: Regioselectivity in the ortho-dialkylaminomethylation of phenols is greatest, for example in reactions of 2, 5_dimethylphenol, when a mixture of the phenol and sulphur dioxide is allowed to stand for several hours before the addition of a bis-(dialkylamino) methane (aminal) or an alkoxydialkylaminomethane (amino1 ether).
