Tetrahedron letters

Synthesis of fragments of the capsular polysaccharide of Haemophilus influenzae type b, comprising two or three repeating units

P Hoogerhout, D Evenberg, CAA Van Boeckel…

Index: Hoogerhout, P.; Evenberg, D.; Boeckel, C. A. A. van; Poolman, J. T.; Beuvery, E. C.; et al. Tetrahedron Letters, 1987 ,  vol. 28,  # 14  p. 1553 - 1556

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Citation Number: 21

Abstract

ABSTRACT: The synthesis of the ribosyl-ribitol derivatives 12 and 1, 7 (Scheme 2) is presented. The compounds served as building blocks for the preparation of protected fragments (2_4, n= l or 2; Fig. 2) of the title polysaccharide. The bifunctional reagent bi. sCl- benzotriazolyll-Z-chlorophenylphosphate(l_S, Fig. 2) was used for all phosphorylation reactions. Attachment to a spacer and complete deprotection of the products, to afford 2_5 ...