The difluorides obtained in the reaction of DAST with appropriate ketones could serve as a suitable starting materials for the selective incorporation of CF2-group into the molecules of the unsaturated chiral natural compounds. As an example, stereoselective synthesis of (R)- 14, 14-difluoro-13-hydroxy-9 (Z), 11 (E)-octadecadienoic acid [(R)-14, 14-difluorocoriolic acid] 6 is reported.
