Frank E. McDonald'*' and Timothy B. Towne Department of Chemistry, Northwestern University 21 45 Sheridan Road, Evanston, Illinois 60208-31 I3 Received April 18, I994 The Cane-Celmer-Westley model for polyether biosynthesis* features enzymatic pol yepoxidation of an acyclic hydroxy polyene (Le., (E,E,E)-premonensin triene - triepoxide), followed by a cascade of intramolecular anti epoxide-opening events to afford the polyether skeleton.334 ...
