… bond formations in conjugate additions of lithiated N-Boc allylamines to nitroalkenes: enantioselective synthesis of 3, 4-and 3, 4, 5-substituted piperidines including (-) …

TA Johnson, MD Curtis, P Beak

Index: Johnson; Curtis; Beak Journal of the American Chemical Society, 2001 ,  vol. 123,  # 5  p. 1004 - 1005

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Citation Number: 109

Abstract

Carbon− carbon bond-forming reactions that create two stereogenic centers with high diastereo-and enantioselectivity in a single step can open new strategic approaches to valued structures. The piperidine ring is the central structure of many biologically active alkaloid natural products and pharmaceuticals. 1 General strategies which have been developed for the synthesis of enantioenriched, substituted piperidines utilize amino acids ...