Comparison of pathways to the versatile synthon of no??carrier??added 1??bromo??4??[18F] fluorobenzene

J Ermert, C Hocke, T Ludwig, R Gail…

Index: Ermert, Johannes; Hocke, Carsten; Ludwig, Thomas; Gail, Rene; Coenen, Heinz H. Journal of Labelled Compounds and Radiopharmaceuticals, 2004 ,  vol. 47,  # 7  p. 429 - 441

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Citation Number: 59

Abstract

Abstract The availability of no-carrier-added (nca) 1-bromo-4-[18 F] fluorobenzene with high radiochemical yields is important for 18 F-arylation reactions using metallo-organic 4-[18 F] fluorophenyl compounds (eg of lithium or magnesium) or Pd-catalyzed coupling. In this study, different methods for the preparation of 1-bromo-4-[18 F] fluorobenzene by nucleophilic aromatic substitution reactions using nca [18 F] fluoride were examined. Of ...