A new, efficient, and straightforward synthesis provides propargylamines in high overall yields (64-77%) by transformation of 1-(arylmethyl)-2-(bromomethyl) aziridines into N, N-di (arylmethyl)-N-(2-propynyl) amines via N-(2, 3-dibromopropyl) amines and N-(2-bromo-2- propenyl) amines. The conversion of N-(2, 3-dibromopropyl) amines into N-(2-bromo-2- propenyl) amines is based on a novel analogue of the Hofmann elimination. A Yamaguchi ...
