Homochiral bidentate phosphine ligands play a vital role in homogeneous transition metal catalyzed asymmetric synthesis. 1 Since the initial reports with BINAP 1 (Scheme 1), 2., , and a wide variety of new biaryl, bidentate ligands have appeared in the literature. 3 However, evidence has been reported to suggest that less electron rich phosphines, like tri-2-furylphosphine 2 (TFP, Scheme 1), are advantageous for some transition metal mediated organic reactions. 4., and These ...
